What are Dissolution Vessels?

Glass Vessel

Good dissolution vessels are critical in obtaining correct and reproducible results and are sometimes overlooked as a key element in the dissolution test.

Amber Vessel

There is no easy way to check the uniformity of the vessel. Most manufacturers provide a certificate of conformance which should be accepted. Measuring the centering of the shaft also helps.

Although the USP states the dimensions for glass vessels, the tolerances are actually quite wide leading to a different dimension for vessels for each manufacturer. This means that vessels cannot easily be interchanged and that it is never advisable to substitute less than a complete set of alternative vessels and even then re-validation may be needed.

Further Information