Advice and information on all aspects of tablet dissolution testing

Vessel Cleaning

It is important that vessels are clean prior to use — this is relevant when using capsules that have sticky coatings. This is for two reasons — there may be contamination of the media which could lead to a high result or the tablet under test may stick to the vessel walls leading to a low result — this tends to show when using prednisone.

Any good laboratory detergent should work well to clean vessels. It can be used with hot water and a soft-bristled brush. Rinse with tap water (the hardness does a great job of removing soap residue) followed by a final rinse of purified water. It may also be necessary sometimes to use a towel wetted with methanol to remove really stubborn residues.